Health Care Active Pharmaceutical Ingredients:
Polyethylene Glycols

PEG APIs: Excellence in Pharmaceutical Applications

Clariant delivers pharmaceutical-grade PEGs with unmatched purity and consistency through 30+ years of manufacturing expertise. Our ICH Q7-compliant production facilities utilize dedicated reactors and undergo rigorous GMP audits, ensuring APIs that meet Ph.Eur., USP-NF, and JP requirements across multiple physical forms.

PEG APIs to bring constipation relief in Laxative formulations

Clariant's PEG-based laxative APIs work through an osmotic mechanism that retains water in the intestine, providing gentle, effective constipation relief. Our products offer significant advantages over alternative treatments: minimal absorption in the digestive tract, absence of side effects compared to lactulose, and suitability for long-term use—even in children as young as two years.

This type of laxative formulation thus improves quality of life for millions around the world, as part of treatment for chronic constipation in adults and children, during pregnancy, before or after surgery or as preparation for colonoscopy continue to improve people’s health.

Our laxative API PEGs are compliant with the general requirements of three of the most important international pharmacopoeias (the European Pharmacopoeia (Ph. Eur.), the United States Pharmacopoeia–National Formulary (USP-NF), and the Japanese Pharmacopoeia (JP)). With more than 30 years experience as a producer, we maintain very rigorous production standards. We use dedicated reactors to avoid cross contamination and our production facilities undergo comprehensive audits for GMP compliance.

Without the right tear composition and amount, people may suffer from conditions which can cause stinging, burning, fatigue and redness of the eyes. Factors such as contact lens wear, increased visual display use and environmental exposure have led to a significant increase in the incidence of eye conditions within modern society^{1, 2}. Lubricant eye drops containing PEG 400 provide temporary relief to the patient. PEG 400 provides a lubrication effect and acts as a demulcent active pharmaceutical ingredient (API) in such formulations³. In the sensitive eye area, high quality ingredients are required in ophthalmic formulations.

Clariant's Polyglykol 400 Jserves as a premium demulcent API in eye drop formulations, forming a protective layer over the ocular surface to relieve inflammation and irritation. This high-quality PEG mimics natural mucins, providing essential lubrication and viscosity for patients suffering from dry eye conditions caused by contact lens wear, digital screen use, and environmental factors. Our product meets stringent microbiological specifications, including endotoxin testing.

1. Stapleton F et al. TFOS DEWS II Epidemiology report. The Ocular Surface 15 (2017) 334-365. 2. Perry HD. Dry Eye Disease: Pathophysiology, Classification and Diagnosis. American Journal for Managed Care 2008;14: 79 – 87 3. FDA, Final Administrative Order OTC000023, “Over-the-Counter Monograph 018: Ophthalmic Drug Products for Over-the-Counter Use,” Section M018.12(d)(3) (available at: https://dps.fda.gov/omuf/monographsearch/monograph_m018).